Image from page 114 of “The Biological bulletin”
Title: The Biological bulletin
Authors: Marine Biological Laboratory (Woods Hole, Mass. ); Marine Biological Laboratory (Woods Hole, Mass. ). Annual report 1907/08-1952; Lillie, Frank Rattray, 1870-1947; Moore, Carl Richard, 1892-; Redfield, Alfred Clarence, 1890-1983
Subjects: Biology; Zoology; Biology; Marine Biology
Publisher: Woods Hole, Mass. : Marine Biological Laboratory
Contributing Library: MBLWHOI Library
Digitizing Sponsor: MBLWHOI Library
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Payment of that grant is conditional upon the MBL raising an additional $2.1 million for the project. With further fundraising success, we hope to break ground for the $8 million building this spring. What a fitting way to celebrate The Ecosystem Center’s 25th anniversary. Josephine Bay Paul Center for Comparative Molecular Biology and Evolution At the Bay Paul Center, 35 scientists and support staff continue to explore a number of aspects of molecular evolution and comparative molecular biology. Their efforts to sequence the genome of Giardia, a water-borne human pathogen that attacks the intestinal tract, is now more than 50 percent complete. Bay Paul Center Director Mitchell Sogin is the principal investigator on that study, which is sponsored by a major grant from the National Institutes of Health. In 1998 the Center welcomed Dr. Michael Cummings to the scientific staff. He is currently investigating ways to accurately predict drug-resistant strains of tuberculosis by examining specific gene sequences. With a recent grant from the Alfred P. Sloan Foundation, he is also developing novel computer-based analytical procedures to study color vision. In January 2000, Dr. Jennifer Wernegreen joined the staff as an Assistant Scientist. Dr. Wernegreen comes to the MBL from the University of Arizona where she was an NIH postdoctoral fellow in the Department of Ecology and Evolutionary Biology. Wernegreen uses comparative approaches to explore the molecular evolution of certain species of bacteria that live symbiotically with specific insects. These bacteria are thought to supplement nutritionally unbalanced diets of their hosts by providing essential amino acids, vitamins, and other nutrients. Other Research Initiatives Elsewhere at the MBL, scientists are working on a variety of biological and biomedical problems. Dr. David Keefe has developed a new method of non-invasively imaging the meiotic spindle of eggs during human in vitro fertilization at his clinic at Women and Infants Hospital in Rhode Island. This technique was developed at the MBL using the polscope designed by Dr. Rudolf Oldenbourg. Application of this exciting technology has doubled the pregnancy rates during intracytoplasmic sperm injection, and improved clinicians’ ability to predict fertilization. Dr. Keefe has also been working with Dr. Peter Smith, Director of the BioCurrents Research Program at the MBL. They have developed a novel approach to measuring oxygen uptake by individual mammalian embryos using a non-invasive, self- referencing oxygen sensor. This work was recognized as one of the 50 most important biotechnology breakthroughs at a special program at the National Institutes of Health. It was also a semi-finalist for the Christopher Columbus Science Innovation Award sponsored by Discover magazine. MBL Distinguished Scientist Shinya Inoue was awarded two patents in 1999 for the Slit Scan Centrifuge Microscope and the Centrifuge Microscope Capable of Realizing Polarized Light Observation. These instruments were developed in collaboration with Olympus Optical and Hamamatsu Photonics Co. Dr. Inoue has been using these and other microscopes that he has developed over the years to study several unexplored attributes of living cells. Over the past year he has taken the first measurements of crawling forces of a cell, shown how mammalian cells can be separated into fractions that only contain certain types of organelles, and recorded thin
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